Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation.
BACKGROUND: Arylamine N-acetyltransferase 2 (NAT2) is an important catalytic enzyme that metabolizes the carcinogenic arylamines, hydrazine drugs and chemicals.This enzyme is highly polymorphic in different human populations.Several polymorphisms of NAT2, including the single amino acid substitutions Enhanced Photocatalytic Degradation Activity of